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15 juin

James Poulet Sensory processing in the mouse forepaw system

Invité par German Sumbre

11h à 12h30

Le séminaire de James Poulet (Max Delbrück Center for Molecular Medecine, Berlin) aura lieu dans la salle Favard, IBENS 46 rue d’Ulm 75005 Paris

Primary motor cortex (M1) neurons are involved in the control of voluntary movements, but also respond to sensory stimulation. To investigate the sensory response heterogeneity in M1 and how sensory input is transformed to motor output we investigated mouse forelimb layer 5 M1 neurons during a novel sensory-triggered reaching task. Single unit recordings revealed two distinct functional cell types. The firing rates of “early” units peaked at short latency (< 50 ms) after the vibrotactile trigger whereas “late” units peaked during movement. Independent measurements including responses to acoustic cue stimuli and recovery dynamics following optogenetic suppression of the vibrotactile response supported the functional split. Reaching amplitude was correlated with early and late cell firing rate and was reduced by pharmacological and optogenetic inhibition of M1. We conclude that early and late neurons are key building blocks for fast sensorimotor transformation in M1.