Christophe LALOI Chromatin insulation : how can a topoisomerase be involved in this kind of function in plants ?
invité par Chris BOWLER - Section Écologie et Biologie de l’Évolution
11h
Le séminaire de Christophe LALOI (Aix-Marseille Université, BIAM (Institut de Biosciences et biotechnologies)) aura lieu dans la salle Favard, IBENS 46 rue d’Ulm 75005 Paris
As in other eukaryotes, the plant genome is functionally organized in two mutually exclusive chromatin fractions, a gene-rich and transcriptionally active euchromatin, and a gene-poor, repeat-rich, and transcriptionally silent heterochromatin. Maintaining sharp boundaries between these chromatin domains with antagonistic functionalities is therefore essential for transcriptional control and involves chromatin insulators that remain largely unknown in plants. I will present the participation of a plant topoisomerase in such an insulator-like function, which prevents the spreading of heterochromatin marks into euchromatin and thus safeguards gene expression in euchromatin islands. Based on the identification of new partners of the topoisomerase, I will discuss possible mechanisms to this insulator-like function.