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20 octobre

Elodie LAINE Assessing the impact of sequence variations on protein functioning

invitée par Amaury LAMBERT - Section Ecologie et Biologie de l’Evolution


Le séminaire d’Élodie LAINE (Laboratory of Computational and Quantitative Biology, Sorbonne Université) aura lieu dans la salle Favard, IBENS 46 rue d’Ulm 75005 Paris

Abstract : Identifying functional protein sites and understanding which and how genetic variations alter them are central questions for bioengineering, medicine, and fundamental biology. I will present some of our recent developments for assessing the impact of sequence variations on how protein function and interact with one another. I will focus on single-point mutations and alternative splicing-induced changes. Our approaches harness the vast reservoir of protein sequence and structural information accessible in public databases. Their efficiency and robustness make them amenable to comprehensive proteome-wide investigations.

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