Damien COUDREUSE Long-term adaptation : when evolution meets cell size
invité par Alice MEUNIER - Section Biologie du Développement
11h à 12h30
Le séminaire de Damien COUDREUSE (Institut de Biochimie et Génétique Cellulaires (IBGC), Bordeaux) aura lieu dans la salle Favard, IBENS 46 rue d’Ulm 75005 Paris
Cell volume is a fundamental and highly controlled phenotypic trait that modulates virtually all aspects of the biology of living cells, from their internal biochemistry to their relationship with the environment. Remarkably, cell volume can vary by several orders of magnitude between species, and even within a given species, distinct populations that have evolved in different geographical niches display a broad range of cell volumes. However, while the mechanisms that sustain short-term cell size homeostasis have been the subject of intense investigation, the fascinating interplay between cell size and evolution has largely remained unexplored. I will share our unpublished study that aimed at unravelling the role of cell volume in long-term adaptation. Taking advantage of state-of-the-art experimental evolution approaches using fission yeast as a model, we probed whether and how the initial size of a cell may delineate its evolutionary trajectory at the phenotypic, genetic and mechanistic levels.