ENS - Départment de biologie

Nathalie JURISCH-YAKSI Guarded by Barriers, Driven by Flow : The Brain's Fluid Secrets

Patricia Mangeny — 2026-06-12T12:00:00Z

14h
Le séminaire de Nathalie Jurisch-Yaksi (Department of Clinical and Molecular Medicine at the Norwegian University of Science and Technology) aura lieu dans la salle Favard, IBENS 46 rue d'Ulm 75005 Paris

- 2026 / Séminaire de l'IBENS

Alice GUILLAUME-MANCA Optique adaptative en microscopie de fluorescence à 2 photons pour la neuro-imagerie fonctionnelle chez la souris

Patricia Mangeny — 2026-06-02T12:00:00Z

14h
La soutenance de thèse d'Alice Guillaume-Manca (IBENS, équipe Bourdieu) aura lieu dans la salle Favard, IBENS 46 rue d'Ulm 75005 Paris

- 2026 / Soutenance de thèse

Prof. Jörg VOGEL ASOs for microbes : Programmable antisense oligomers for selective targeting of bacteria, hosts and phages

Patricia Mangeny — 2026-05-29T10:00:00Z

12h
Le séminaire du Prof. Jörg Vogel (Professor at the University of Würzburg and Director of the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg) aura lieu dans la salle Favard, IBENS 46 rue d'Ulm 75005 Paris

- 2026 / Séminaire de l'IBENS

Catherine BOURGAIN Promesses et gouvernement des technosciences. Comment les anticipations du futur façonnent les recherches et l'innovation biomédicale ?

Patricia Mangeny — 2026-05-26T10:00:00Z

12h
Le séminaire de Catherine Bourgain (Centre de Recherche Médecine, Sciences, Santé, Santé mentale, Société, (Cermes3), Villejuif et Paris) aura lieu dans la salle Favard, IBENS 46 rue d'Ulm 75005 Paris

- 2026 / Séminaire de l'IBENS

Simon ALBERTI Kinetic Solubility as a Principle of Cellular Organization

Patricia Mangeny — 2026-05-26T09:30:00Z

11h30
Le séminaire de Simon Alberti (Technical University of Dresden, Dresden, Allemagne) aura lieu dans l'salle Amphithéâtre Galois, 45 rue d'Ulm 75005 Paris

- 2026 / Séminaire de l'IBENS

Dr. Juan CANTALAPIEDRA What fossil mammals teach us about evolution

Patricia Mangeny — 2026-05-22T10:00:00Z

12h
Le séminaire du Dr. Juan Cantalapiedra (Museo Nacional de Ciencias Naturales (CSIC), Madrid) aura lieu dans la salle de Conférence, IBENS 46 rue d'Ulm 75005 Paris

- 2026 / Séminaire de l'IBENS

Richard EBRIGHT Structural basis of factor-dependent and intrinsic transcription termination

Patricia Mangeny — 2026-05-12T09:30:00Z

11h30
Le séminaire de Richard Ebright (Waksman Institute, Rutgers University, Piscataway, NJ, USA) aura lieu dans l'Amphithéâtre Galois, 45 rue d'Ulm 75005 Paris

- 2026 / Séminaire de l'IBENS

Seth GRANT The architecture of synapse diversity in health and disease

Patricia Mangeny — 2026-05-11T09:00:00Z

11h

Le séminaire de Seth Grant (Edinburgh University, UK) aura lieu dans la salle des Résistants (1er étage, escalier A), 45 rue d'Ulm 75005 Paris

The brain's defining feature is its enormous number of synaptic connections. Traditionally, synapses were thought to fall into only a few broad classes—excitatory, inhibitory, or modulatory—based largely on neurotransmitter identity. The advent of synaptome mapping, which enables systematic, single-synapse–resolution analysis across the entire mouse brain, has overturned this view. These studies reveal an unexpectedly vast diversity of synapse types and their organisation into a highly structured three-dimensional map known as the synaptome architecture. This architecture provides a powerful new framework for understanding how innate and learned behaviours are encoded, how neurological and psychiatric diseases selectively target specific synapse populations, and how therapeutic drugs act on brain circuits. Our current work is focussing on the synaptome architecture of the human brain in health and disease.

Pierre BADUEL Transposable elements as vectors of allelic and- epiallelic exploration and their contribution to plant- genome evolution

Patricia Mangeny — 2026-05-05T12:00:00Z

14h
La soutenance HDR de Pierre Baduel (IBENS, équipe PEpiTE) aura lieu dans la salle Favard, IBENS 46 rue d'Ulm 75005 Paris

- 2026 / Soutenance d'HDR

Jacques WADICHE Local and diffuse actions of glutamate

Patricia Mangeny — 2026-04-27T09:00:00Z

11h

Le séminaire de Jacques Wadichet (University of Alabama at Birmingham Medical School) aura lieu dans la salle 316, IBENS 46 rue d'Ulm 75005 Paris

Glutamate signaling is often viewed as a highly local process in which transmitter released at anatomically defined synapses activates precisely aligned postsynaptic receptors. However, glutamate can also diffuse beyond the synaptic cleft, influencing nearby cells and receptors in ways that are not captured by classical wiring diagrams. In this talk, I will discuss how both local and diffuse glutamate signaling shape excitatory transmission in the cerebellar cortex. First, I will show that spillover from climbing fibers excites molecular layer interneurons (MLIs) through extrasynaptic mechanisms, functionally segregating interneurons according to their spatial relationship with the release site and altering inhibition of neighboring Purkinje cells. Next, I will describe how climbing fiber spillover can also recruit Ca2+-permeable AMPA receptors at parallel fiber synapses, revealing a form of “spill-in,” in which glutamate released from one pathway engages receptors associated with another. Finally, I will present evidence that the glutamate concentration landscape itself regulates key AMPA receptor properties, demonstrating that receptor behavior is shaped not only by subunit composition but also by the amount of glutamate reaching the receptor. Together, these findings support a broader view of excitatory signaling in which glutamate acts both locally and diffusely to influence receptors, synapses, and circuits.