ENS - Départment de biologie

Hocine REKAIK Engineering development : Reconstructing HOX-dependent programs of tissue patterning and morphogenesis

Patricia Mangeny — 2026-07-01T08:30:00Z

10h30

Le séminaire de Hocine Rekaik (CIRB, Paris) aura lieu dans la salle Favard, IBENS 46 rue d'Ulm 75005 Paris

Abstract : A fundamental challenge in developmental biology is to understand how positional information is translated into the coordinated processes of cell fate specification, tissue patterning, and morphogenesis. Hox genes are key regulators of positional identity, yet the mechanisms by which combinatorial HOX activities instruct the formation of complex tissues remain poorly understood. To address this question, I recently established a Hox-null mouse embryonic stem cell platform that enables the synthetic reconstruction of HOX-dependent developmental programs in gastruloid and organoid systems. In this seminar, I will present recent advances from this work and discuss a research program aimed at reconstructing developmental gene regulatory networks to establish a predictive understanding of how positional identity drives the generation of organized tissues.

Julie STOUFFLET From brain development in health and disease to spine-on-chip model to study human spinal cord development

Patricia Mangeny — 2026-06-30T08:00:00Z

10h

Le séminaire de Julie Stoufflet aura lieu dans la salle Favard, IBENS 46 rue d'Ulm 75005 Paris

Abstract : The development of the human central nervous system starts by the closure of the neural tube between day 23 to 30 of gestation. This event leads to the formation of two important regions : the brain in the rostral part and the spinal cord in the caudal part. The brain is a complex organ that control and process thought, memory, emotion, sensation, movement etc. and the spinal cord is the relay between the body and the brain and conduct sensory and motor information. During my PhD and my first postdoc, I tried to understand how newborn neurons migrate to settle in the appropriate region of the brain in mice and how their migration is affected in some diseases such as ciliopathies or prenatal alcohol exposure. However, animal models present significant limitations in the understanding of human development. Therefore, to fully understand the human central nervous system development and recapitulate human diseases, new experimental models need to be developed. During my second postdoctoral project, I developed organ-on-chip approaches to model human spinal cord development in vitro. The spinal cord provides a powerful system to study how morphogens generate cellular diversity, as opposing signaling centers organize the neural tube into 11 molecularly distinct progenitor domains. Using engineered human spinal cord models with precise spatial and temporal control of morphogen delivery, we generated a 2D model of spinal cord recapitulating both the cellular diversity and the spatial organisation of progenitors observed in the ventral neural tube. Our ventral human spinal cord is perfectly suitable to investigate a fundamental question in developmental biology : how morphogens are transported through developing tissues to generate robust and reproducible patterns such as the respective contributions of diffusion, transcytosis, and cytoneme-mediated transport to morphogen propagation and neural tissue organization.

Adrien PEYRACHE Orienting memories during wake and sleep

Patricia Mangeny — 2026-06-29T09:00:00Z

11h à 12h30
Le séminaire d'Adrien Peyrache (Montreal Neurological Institute, McGill University, Canada) aura lieu dans la salle Favard, IBENS 46 rue d'Ulm 75005 Paris

- 2026 / Séminaire de l'IBENS

Pierre VERON Fossé micro–macro dans la recherche sur la spéciation : identifier les processus micro-évolutifs qui expliquent les différences de diversification entre lignées

Patricia Mangeny — 2026-06-25T12:00:00Z

14h0
La soutenance de thèse de Pierre Veron (co-encadrée par Hélène Morlon, IBENS et Tatiana Giraud, Université Paris-Saclay) aura lieu dans la salle Favard, IBENS 46 rue d'Ulm 75005 Paris

- 2026 / Soutenance de thèse

Dr. Miguel SALINAS SAAVEDRA Evolution of Tissue Morphogenesis : What Can We Learn from Cnidarians and Ctenophores ?

Patricia Mangeny — 2026-06-24T09:00:00Z

11h à 12h30
Le séminaire du Dr. Miguel Salinas Saavedra aura lieu dans la salle Favard, IBENS 46 rue d'Ulm 75005 Paris

- 2026 / Séminaire de l'IBENS

ABC_Artificial Cell

Bofei MA — 2026-06-23T15:21:41Z

- À découvrir / Focus fixe

ABC_Epidemiology

Bofei MA — 2026-06-23T15:06:44Z

Matthieu BOULARD The Chromatin Mechanism that Governs Olfactory Receptor Gene Choice

Patricia Mangeny — 2026-06-22T09:00:00Z

11h à 12h30
Le séminaire de Matthieu Boulard (EMBL, Rome) aura lieu dans la salle Favard, IBENS 46 rue d'Ulm 75005 Paris
Abstract : A transcription mechanism generates an extraordinarily high neural diversity in the olfactory epithelium. This scarcely understood biological process, referred to as olfactory receptor gene choice, results in the transcription of a single olfactory receptor gene per neuron, randomly selected from 1000 paralogous genes. I will present functional data in vivo (…)

- 2026 / Séminaire de l'IBENS

Robin JOURNOT From developmental organogenesis to directed maturation : a data-driven framework for engineering epithelial cell fate

Patricia Mangeny — 2026-06-17T09:00:00Z

11h
Le séminaire de Robin Journot (IHB, Bâle, Suisse) aura lieu dans la salle Favard, IBENS 46 rue d'Ulm 75005 Paris

- 2026 / Séminaire de l'IBENS

Sandhya KOUSHIKA Axonal mitochondria-mediated actin dynamics in escape responses

Patricia Mangeny — 2026-06-16T12:00:00Z

14h
Le séminaire de Sandhya Koushika (Department of Biological Sciences,
Tata Institute of Fundamental Research, Mumbai, Inde) aura lieu dans la salle Favard, IBENS 46 rue d'Ulm 75005 Paris

- 2026 / Séminaire de l'IBENS