ENS - Départment de biologie

Jean-Philippe PIN Innovative approaches to control brain functions with mGluRs

2016-12-19T10:00:00Z

11h à 12h30
Le séminaire de Jean-Philippe PIN (Institut de Génomique Fonctionnelle, Université de Montpellier) aura lieu dans la salle Favard, IBENS 46 rue d'Ulm 75005 Paris

- 2016 / Séminaire de l'IBENS

Isabelle Baginski NanoLuc Luciferase for Protein/Protein interactions study : NanoBRET & NanoBiT assays

2016-12-13T14:00:00Z

protein interactions (PPI) are essentials for cell signals transduction. Many approaches exist to study PPI in vitro, but intracellular detection methods are limited. We developed, thanks to Nanoluciferase, different technologies as NanoBRET or NanoLuc® Binary Technology NanoBiT, an in vivo complementation system using 2 sub-units named Large BiT (LgBiT, 18kDa) and Small BiT (SmBiT, 11 amino acids) expressed in fusion with protein of interest for PPI study.
Technical aspects, advantages and applications (as real-time study of PPI) of these tools will be presented.

- 2016 / IBENS Protein Meeting

Dr. Stephan PLESS Atomic-scale manipulations to study ion channel function and pharmacology

2016-12-07T13:00:00Z

14h à 15h30
Le séminaire du Dr. Stephan PLESS (University of Copenhagen) aura lieu dans la salle Favard, IBENS 46 rue d'Ulm 75005 Paris

- 2016 / Séminaire de l'IBENS

Dominique Gagliardi mRNA uridylation and decay

2016-12-02T10:00:00Z

The post-transcriptional addition of nucleotides impacts function and fate of RNAs in all organisms. In recent years, uridylation emerges as a key modification promoting mRNA degradation in eukaryotes. Yet, we are just beginning to understand the exact roles of uridylation in the degradation process. mRNA uridylation can favor both 5'-3' and 3'-5' degradation through the recruitments of distinct RNA decay factors. In addition, uridylation prevents the accumulation of excessively deadenylated mRNAs in Arabidopsis. To obtain a global view of mRNA 3' end modifications, we deep-sequenced the 3' fragments of mRNAs using TAIL-seq, a method recently developed by the Narry Kim's lab. This analysis revealed the prevalence of mRNA uridylation in Arabidopsis and the occurrence of mRNA cytidylation and guanylation at lower frequencies. Interestingly, uridylation of mRNAs by distinct Terminal Uridylyl Transferases (TUTases) seems to differentially affect mRNA's fate. The complexity of mRNA uridylation and its emerging roles will be discussed.

- 2016 / Séminaire de l'IBENS

Julien FALK Molecular memory of morphologies by Septins during neuron generation

2016-12-02T09:00:00Z

10h à 11h
Le séminaire de Julien FALK (Institut NeuroMyoGene, Université Claude Bernard - Lyon 1) aura lieu dans la salle Favard, IBENS 46 rue d'Ulm 75005 Paris

- 2016 / Séminaire de l'IBENS

Séminaire Annuel du Labex MemoLife

Frédérique Godfroid — 2016-11-23T12:30:00Z

Séminaire Annuel du Labex MemoLife

Mercredi 23 novembre 2016
de 13h30 à 17h30 en Salle Dussane

Ecole Normale Supérieure
45, rue d'Ulm • 75005 Paris

Programme du Séminaire

Claude DESPLAN Generating neural diversity and retinotopy in the visual system

Frédérique Godfroid — 2016-11-21T09:30:00Z

10h30 à 12h
Le séminaire de Claude DESPLAN, New-York University, aura lieu le 21 novembre 2016 dans la
Salle Favard IBENS 46, rue d'Ulm 75005 Paris

- 2016 / Séminaire de l'IBENS

Ben Kerr Historical Contingency in Changing Environments

2016-11-16T10:00:00Z

Evolutionary biologists have entertained different perspectives regarding the importance of historical contingency in adaptive evolution. To some extent, these perspectives boil down to whether the context-dependent effects of mutations meaningfully influence evolutionary trajectories. Because the fitnesses of genotypes intimately depend on the form of the environment, environmental change may set the stage for historical contingency. In this talk, I will discuss how the rate and form of environmental change can affect evolutionary trajectories. I will share results from experiments with microbes and digital organisms that explore contingency under changing conditions. In the process, I will touch on how our findings relate to some pressing anthropogenic problems, such as climate change and the rise of antibiotic resistance. These experiments not only suggest that context-dependent effects of mutations can impact the course of adaptive evolution, but also may highlight under-appreciated areas of focus with regard to addressing current societal problems.

- 2016 / Séminaire de l'IBENS

Sébastien Pfeffer Regulation of RNA silencing processes during viral infections

2016-11-04T10:00:00Z

11h à 12h30
Le séminaire de Sébastien Pfeffer (IBMC, Université de Strasbourg) aura lieu dans la salle Favard, IBENS 46 rue d'Ulm 75005 Paris

- 2016 / Séminaire de l'IBENS

Katsuhiko MIKOSHIBA Physiology and pathophysiology of Ca2+ signaling

2016-10-20T09:00:00Z

11h à 12h30
Le séminaire de Katsuhiko MIKOSHIBA (RIKEN Brain Science Institute, Japan) aura lieu dans la salle Favard, IBENS 46 rue d'Ulm 75005 Paris

- 2016 / Séminaire de l'IBENS

ENS - Départment de biologie

Jean-Philippe PIN Innovative approaches to control brain functions with mGluRs

Isabelle Baginski NanoLuc Luciferase for Protein/Protein interactions study : NanoBRET & NanoBiT assays

Dr. Stephan PLESS Atomic-scale manipulations to study ion channel function and pharmacology

Dominique Gagliardi mRNA uridylation and decay

Julien FALK Molecular memory of morphologies by Septins during neuron generation

Séminaire Annuel du Labex MemoLife

Séminaire Annuel du Labex MemoLife

Mercredi 23 novembre 2016 de 13h30 à 17h30 en Salle Dussane

Claude DESPLAN Generating neural diversity and retinotopy in the visual system

Ben Kerr Historical Contingency in Changing Environments

Sébastien Pfeffer Regulation of RNA silencing processes during viral infections

Katsuhiko MIKOSHIBA Physiology and pathophysiology of Ca2+ signaling

Mercredi 23 novembre 2016
de 13h30 à 17h30 en Salle Dussane