Laurent DURET Prevalence of Prdm9-dependent meiotic recombination hotspots in animals
invité par Henrique TEOTÓNIO - 2024-2025 EEB external seminar
12h
Le séminaire de Laurent DURET (LBBE, Université Lyon) aura lieu dans la salle Favard, IBENS 46 rue d’Ulm 75005 Paris
Abstract : In many eukaryotes, meiotic recombination occurs preferentially at discrete sites, called recombination hotspots. In various lineages, recombination hotspots are located in regions with promoter-like features and are evolutionarily stable. Conversely, in some mammals, hotspots are driven by PRDM9 that targets recombination away from promoters. Paradoxically, PRDM9 induces the self-destruction of its targets and this triggers an ultra-fast evolution of mammalian hotspots. The reasons for the existence of these two categories of hotspots are unclear. PRDM9 is ancestral to all animals, suggesting a critical importance for the meiotic program, but has been lost in many lineages with surprisingly little effect on meiosis success. To try to understand the ‘raison d’être’ of these different types of hotspots, we investigated the activity of Prdm9-dependent and Prdm9-independent recombination hotspots in several clades. I will present an overview of these analyses.