Lisa ROUX Breathing and hippocampal network activity during wake and sleep
IBENS Neuroscience Seminar
11h à 12h30
Le séminaire de Lisa ROUX (Interdisciplinary Institute for Neuroscience (IINS), Université de Bordeaux, France) aura lieu dans la salle Favard, IBENS 46 rue d’Ulm 75005 Paris
Brain activity and breathing rate influence each other but it remains unclear how the fine respiratory cycle features (e.g. inhalation amplitude or duration) impact neuronal network dynamics. By recording nasal pressure and neuronal activity in freely-moving mice, we detected respiratory pauses nested within breathing cycles that are characterized by a large variability in their duration. In wakefulness, these pauses largely dictate the respiratory rate of the animals and their onset marks drastic changes of neuronal activity when the latter is recorded within silicon probes in the olfactory piriform cortex and the hippocampus. Pause properties discriminate Wake, rapid eye movement (REM) and non-REM (NREM) sleep and accompany the infra-slow oscillations of noradrenaline and sigma power observed in NREM sleep. This seminar will address how the fine respiratory features coordinate with hippocampal circuit dynamics both in wake and sleep and reveal new relationships between brain functions and respiration.