TBA Plus d'infos... Tags: Wolfram, Holy Grail, Middle High German literature, Conrad Wolfram, Catherine Wolfram Annonce publiée le 08-11-2023 |
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Laboratoire Jean Perrin Laboratoire Jean Perrin - Campus Jussieu - T 32-33 - 5e et. - P533 |
TBA Plus d'infos... Tags: Wolfram, Holy Grail, Middle High German literature, Conrad Wolfram, Catherine Wolfram Annonce publiée le 08-11-2023 |
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Laboratoire Jean Perrin Laboratoire Jean Perrin - Campus Jussieu - T 32-33 - 5e et. - P533 |
Invite par: Cassandra Koh Keywords: drug abuse, neurodevelopment, extracellular vesicles, basic science Plus d'infos... Annonce publiée le 29-12-2023 |
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Institut Pasteur Batiment Jacob, salle Auditorium Francois Jacob, |
DNA methylation is a broadly observed epigenetic modification. As genomic DNA methylation profiles dynamically change during development and aging, alterations in DNA methylation patterns are linked to diseases such as cancers and immunodeficiency. ICF syndrome is characterized by hypomethylation at heterochromatin. Of four proteins whose mutation cause ICF syndromes (DNMT3B, ZBTB24, CDCA7 and HELLS), we have previously demonstrated that CDCA7 is a critical activator for the nucleosome remodeling activity of the SNF2-family ATPase HELLS. As DNA methyltransferases cannot directly methylate DNA on the nucleosome, we suggested that the CDCA7-HELLS complex assists DNA methyltransferases by sliding DNA on the nucleosome. However, it remained unclear why the CDCA7-HELLS complex, among several SNF2-family proteins that can remodel nucleosomes, plays a unique role in DNA methylation. Here, I will share our efforts to fill this gap by showing that CDCA7 is an adaptor for hemimethylated CpG. Implications of this finding for diseases will be discussed. Séminaire proposé par Nicolas Manel Plus d'infos... Tags: DNA, Epigenetics, DNA methylation, Chromosomes, DNMT3B, ICF, Centromere, Constitutive heterochromatin Annonce publiée le 08-03-2024 |
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Institut Curie Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e |
Plus d'infos... Tags: Virus, Hepatitis, Antiviral drug, Viral hepatitis Annonce publiée le 19-05-2024 |
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Saints Peres Neuroscience salle Curie A, 45 rue des Saints Peres 75006 |
La taille des cellules joue un rôle crucial dans le fonctionnement de divers types de cellules dans tout le corps humain, influençant la structure des organites, la biosynthèse et les processus de transport en surface. Bien que certains gènes influençant la taille des cellules aient été identifiés, les mécanismes moléculaires par lesquels la croissance cellulaire initie la division cellulaire restent largement inconnus. Contrairement aux attentes selon lesquelles la croissance renforcerait l’activité des kinases dépendantes des cyclines (Cdks), connues pour faciliter la division cellulaire, nos résultats suggèrent le contraire. À savoir, cette croissance cellulaire provoque la division en diluant les protéines qui inhibent la division, en particulier Whi5 dans la levure et le suppresseur de tumeur du rétinoblastome (Rb) dans les cellules humaines. Cela a identifié la « dilution des inhibiteurs » comme un mécanisme critique reliant la croissance cellulaire à la division cellulaire. Nous rapportons ici nos nouvelles découvertes sur les mécanismes moléculaires distincts responsables de la diminution des concentrations de Rb et de Whi5 en phase G1. Nos résultats soulignent les stratégies moléculaires complexes utilisées par les cellules eucaryotes pour mettre en œuvre la stratégie conservée consistant à diluer les inhibiteurs du cycle cellulaire pendant la phase G1 afin de coordonner la croissance cellulaire avec la division. Plus d'infos... Annonce publiée le 26-04-2024 |
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Institut Curie Centre de recherche - Paris - Amphitheatre Constant-Burg - 12 rue Lhomond, Paris 5e |
Les participants auront l'occasion : Le cours « NON-CODING GENOME » explorera la diversité des éléments d'ADN non géniques et des ARN non codants dans un large spectre de processus cellulaires, chez l'homme et les organismes modèles, ainsi que leur implication dans la physiologie et la pathologie. Des experts de renommée internationale présenteront leurs dernières découvertes relatives à l'identification et à la caractérisation fonctionnelle du génome non codant et discuteront de nouveaux concepts en matière de régulation et d'évolution du génome, en mettant l'accent sur les outils expérimentaux et informatiques. Les sessions thématiques incluront des ARN non codants longs et petits, des éléments transposables, des répétitions d'ADN structurel et des éléments régulateurs non codants. Ce cours offrira aux jeunes étudiants et aux chercheurs l’occasion d’élargir leurs connaissances et de discuter de leurs travaux avec une communauté scientifique internationale dans un environnement stimulant de l’Institut Curie à Paris. Plus d'infos... Annonce publiée le 29-02-2024 |
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Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) |
Invited by Antoine Zalc. Plus d'infos... Tags: Max Planck Institute of Molecular Cell Biology and Genetics, Max Planck Society, Cell and molecular biology Annonce publiée le 29-02-2024 |
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Institut Cochin Salle Rosalind Franklin |
Invite par: ESCHBACH Claire Plus d'infos... Tags: Computational neuroscience, Cognitive neuroscience, Animal models, Neuroinformatics, Gregory Jefferis, Connectome, Drosophila Annonce publiée le 25-01-2024 |
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NeuroPSI Salle de conference Albe-Fessard |
Invite par: Emmanuelle FABRE Cells can rapidly and reversibly adopt distinct states and this can occur independently of genetic alterations, a biological mechanism commonly referred to as cell plasticity. CD44 is a plasma membrane glycoprotein associated with development, immune cell activation as well as tumorigenesis. Although often described as a cell-surface marker, the biological function of CD44 remains elusive. We discovered that CD44 mediates the uptake of metals including copper and iron bound to hyaluronates in cells from distinct tissues. This glycan-mediated metal endocytosis mechanism is enhanced during immune cell activation and in cancer cells undergoing epithelialmesenchymal transition. We found that copper(II) catalyzes a previously uncharted chemical reaction in mitochondria required for the production of key metabolites. In contrast, iron is required in the nucleus to promote the activity of specific demethylases. Together, these metals orchestrate metabolic and epigenetic programming of cell plasticity, establishing CD44 as a regulator of cell state transition. We developed new classes of small molecules that selectively interfere with these metal-catalyzed chemical processes in cells. Supformin specifically targets mitochondrial copper(II), thereby antagonizing macrophage activation in several pre-clinical models of acute inflammation and cancer. This validates a key concept in biology whereby pharmacological control of cell plasticity confers therapeutic benefits. This also suggest a competition for metal uptake by immune and cancer cells that may enable tumor progression. Structurally distinct classes of small molecule were developed to manipulate lysosomal iron providing control of cell fate with induction of or protection against ferroptosis . These findings illuminate a universal metal uptake mechanism and the critical role of metals as master regulators of cell plasticity, paving the way towards the development of next generation therapeutics. Plus d'infos... Annonce publiée le 05-04-2024 |
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UMR7212-U944 Batiment Jean Bernard INSERM U944 UMR7212 IRSL Hopital St Louis 16 rue de la Grange aux Belles 75010 PARIS |
Plus d'infos... Tags: Cancer Annonce publiée le 08-10-2023 |
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Centre de Recherche des Cordeliers amphitheatre Gustave Roussy, 15 rue de l'Ecole de Medecine - 75006 |
Plus d'infos... Annonce publiée le 15-05-2024 |
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Institut Cochin Salle Rosalind Franklin |
23 May 2024 at 5pm Auditorium F. Jacob or Teams : Click here to join the meeting In the continuity of the Quart d’heure Pasteur proposed since 2015, the Medical Department would like ... Plus d'infos... Tags: Grand Cross of the Legion of Honour, Louis Pasteur Annonce publiée le 27-04-2024 |
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Institut Pasteur Batiment: F. Jacob Salle: Auditorium |
Invite par: Hugues de The - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 18-04-2024 |
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College de France Amphitheatre Halbwachs, 11 place Marcelin-Berthelot, 75005 Paris |
Invite par: FEREZOU Isabelle Plus d'infos... Annonce publiée le 27-04-2024 |
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NeuroPSI Salle de conference Albe-Fessard |
A key role of central nervous systems is to drive the musculoskeletal system to move. Hence, a large proportion of the mammalian nervous system spread across diverse regions is used to drive movement. In humans, diseases or injuries to any of these regions can lead to impairments in movement, whether hypokinetic or hyperkinetic. Understanding how these diseases affect the integrated neural circuits in these different regions to impair the wonderful symphony of movement could lead to both a better understanding of nervous system physiology, and improved treatments for these patients. In this talk, I will focus on one disease: DYT-TOR1A dystonia, a generalised, early-onset dystonia resulting from a single gene mutation. I will attempt to take you through our iterative journey from patients to new mouse models and back to patients, and to discuss what we have learned about movement and about dystonia Plus d'infos... Tags: Neurological disorders, Dystonia, Hyperkinesia, Hypokinesia, Congenital disorders, Movement disorder Annonce publiée le 19-05-2024 |
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Saints Peres Neuroscience salle de conferences R229, Campus Saint Germain des Pres de l'Universite de Paris Cite, 45 rue des Saints Peres 75006 |
Invite par: Fabiola Terzi amp; Marco Pontoglio Marcelle Machluf received her Ph.D. in Biotechnology Engineering from Ben-Gurion University (Israel), and then went on to complete a 5-year post-doctoral fellowship at the Harvard Medical School under the supervision of distinguished scholars Robert Langer and Anthony Atalla. During these years, she gained extensive hands-on experience with biomaterials and the development of biomedical platforms.Since joining the Technion in 2001, Dr. Machluf's research has focused on nature inspired biomaterials, drug delivery, and regenrative medicine, which have resulted in more than 90 peer-reviewed journal papers and over 200 conference papers. In 2017, she was nominated Dean of the Faculty of Biotechnology and Food Engineering at the Technion. She has supervised more than 50 graduate and post-doctoral students, from around the world. In recent years, she was a member of the TargetCaRe consortium, under Horizon 2020 Training Networks (H2020-MSCA-ITN-2014), as well as the head of a six-year collaboration between six groups from the Technion and two of Singapores leading universities (NTU and NUS) funded for 25M$ by the National Research Foundation of Singapore. Her research has fruited in more than 90 peer-reviewed journal papers (~6,500 citations, h-index 45), 7 patents, and two startup companies NanoGhost and Meatafora.Currently Marcelle Machluf's team is advancing the resesarch on the proprietary NanoGhost technology, which is a nanometric delivery system prepared from the isolated cytoplasmatic membranes of mesenchymal stem cells (MSCs). This platform was shown to retain the membranal molecules of MSCs, thus preserving these cells capability to actively target the tumor niche and inflammation sites, and to modulate local immune reactions while carrying therapeutic drugs. Established evidence of the NanoGhost platform efficacy in the treatment of multiple cancer types and chronic inflammation diseases, has led to its recent commercialization. Seminar Topic: Nanoghost: a smart targeted cancer drug delivery system or a therapy as well? Plus d'infos... Tags: Science and technology in Israel, Marcelle Machluf, Technion Israel Institute of Technology, Mesenchymal stem cell, Biomaterial Annonce publiée le 18-05-2024 |
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Institut Necker Enfants Malades Auditorium 1 |
Invite par: Cyril Renassia Annual symposium of the Labex IBEID A day dedicated to the scientific work of the Labex IBEID partners. This year we will have the pleasure to welcome Prof Bernhard Hube from Lebniz-Hans Knoll Institute. ... Plus d'infos... Tags: Hube, LabEx ReFi - European Laboratory on Financial Regulation, French National Centre for Scientific Research Annonce publiée le 04-04-2024 |
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Institut Pasteur Batiment: Duclaux Salle: Amphitheatre Duclaux |
Invite par: Michael Nilges Wim Degrave Coordinator, Program for Technological Development of Health Products - seminar Oswaldo Cruz Foundation - Rio de Janeiro - Brazil Invited by Michael Nilges -Technology Department Plus d'infos... Tags: Oswaldo, Brazil, Rio de Janeiro Annonce publiée le 01-05-2024 |
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Institut Pasteur Batiment Batiment CFJ, salle Salle Auditorium Centre Francois Jacob , |
Presentation
Les sols sont le support de la vie terrestre et le substrat de la vegetation. Ce sont des ecosystemes complexes et fragiles qui contribuent a la qualite de notre environnement. Leur etude est, par essence, pluridisciplinaire et se situe au carrefour de la geologie, de la physique, de la chimie, de la biologie, de l'agriculture et de la climatologie. Leurs caracteristiques physicochimiques et biologiques conditionnent la nature de la vegetation, la qualite et le rendement des cultures. Les pratiques de l'agriculture intensive et industrielle les appauvrissent considerablement dans nombre de regions du globe, y compris dans notre pays et il convient d'en prendre conscience et de tenter d'y remedier. Les sols contribuent aussi au stockage et au piegeage du gaz carbonique, au travers de la mineralisation de la matiere organique, et sont donc un puits de carbone, mais ils peuvent aussi, dans certaines conditions, en liberer et devenir une source supplementaire de ce gaz a effet de serre. Leur gestion est donc un facteur important a maitriser dans les efforts pour attenuer le changement climatique .
L'objectif de cette seance, commune avec l'Academie d'agriculture de France est de faire un point des connaissances sur quelques aspects de la science des sols et sur les enjeux qui s'y rattachent. Plus d'infos... Annonce publiée le 18-05-2024 |
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Academie des Sciences 23 quai de Conti - 75006 Paris |
Organoids are lumen-containing multicellular structures that recapitulate key features of the organs. We will first present a microfluidic technology that allows to produce them at high throughput in individual hydrogel capsules. Then we will investigate their growth dynamics, their unique mechanical properties and some instabilities that are remarkably reminiscent of stages in embryo development. Plus d'infos... Tags: Microfluidics, Tissue engineering, Biotechnology, Stem cells, Nanotechnology, Organoid Annonce publiée le 18-05-2024 |
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Laboratoire Jean Perrin Laboratoire Jean Perrin - Campus Jussieu - T 32-33 - 5e et. - P533 |
The presentation will focus on our recent and ongoing work in the fields of MRI-guided radiotherapy (and sentinel node biopsy) and on the development of microphysiological culture systems for radiobiological studies. In close collaboration with Ferronova, our team is developing a family of MRI contrast agent based on iron oxide nanoparticles. The first generation of the FerroTrace technology is targeted to lymphoid cells via small molecule ligands and a polymeric coating designed to mitigate the protein corona. On the back of a now completed successful Phase 1 trial in cancer of the oral cavity (ACTRN12620000831987), the MAGICSENT multi-centre trial (ACTRN12621000748819) is now underway with a focus of upper gastrointestinal cancer. Leveraging the expertise gained in developing FerroTrace, our team is presently developing a molecular MRI agent targeted to tumour tissues towards enhancing tumour margin detection and consequently treatment guidance/planning. A specific focus is on the Fibroblast activation protein (FAP), an extracellular transmembrane protein expressed in the stromal and vascular tumour microenvironment of most carcinoma. Recognising the potential of microphysiological culture systems in delivering new radiobiological knowledge and the importance of controlling the in vitro culture environment, the talk will also briefly discuss several approaches developed at the University of South Australia. For example, I will discuss the use of a 3D printed cassette that enables high throughput measurements of the proton Relative Biological Effectiveness (RBE) along Spread-Out Bragg Peaks. Plus d'infos... Annonce publiée le 16-05-2024 |
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Institut Curie Centre de recherche - Orsay - Amphitheatre du Batiment 111 |
Invite par: Pierre-Antoine Defossez Plus d'infos... Tags: Epigenetics, Post-translational modification, Chromatin, Crosstalk Annonce publiée le 19-05-2024 |
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Epigenetique et Destin Cellulaire Institut Jacques Monod seminar room (RB-18B). Batiment Buffon, 15 rue Helene Brion, Paris 13th |
The dynamics of biological systems, from proteins to cells to organisms, is complex and stochastic. To decipher their physical laws, we need to bridge between experimental observations and theoretical modeling. Thanks to progress in microscopy and tracking, there is today an abundance of experimental trajectories reflecting these dynamical laws. Inferring physical models from imperfect experimental data, however, is challenging and currently remains a bottleneck to data-driven biophysics. In this talk, I will present a set of tools developed to bridge this gap and permit robust and universal inference of stochastic dynamical models from experimental trajectories. These methods are rooted in an information-theoretical framework that quantifies how much can be inferred from Plus d'infos... Tags: Stochastic processes, Complex systems theory, Dynamical system, Systems theory, Stochastic, Macroeconomic model, Self-organization, Jinqiao Duan, Supersymmetric theory of stochastic dynamics Annonce publiée le 03-05-2024 |
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Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie |
The small interfering RNA pathway constitutes a pivotal antiviral defense against RNA viruses in insects, functioning through RNA interference mediated by Ago2-guided cleavage of viral genomes. This systemic mechanism requires the recognition and transport of double-stranded RNA (dsRNA) of viral origin. Despite the known cellular uptake of dsRNA through endocytosis, the specific protein(s) responsible for this internalization remain elusive. Here, we investigate the role of Hsc70-4, a cytosolic protein known for its chaperone activity, as a potential cell surface receptor or co-receptor for dsRNA internalization in the insect model Drosophila melanogaster. Immunofluorescence assays were conducted on permeabilized and non-permeabilized S2 cells using a specific anti-Hsc70-4 antibody to determine its subcellular localization. Permeabilized cells exhibited cytoplasmic and plasma membrane staining, whereas non-permeabilized cells showed punctate staining on the outer surface of the plasma membrane, indicating the presence of Hsc70-4 in the cell surface. To assess the role of Hsc70-4 as a receptor/co-receptor for dsRNA uptake, we employed immunofluorescence and luciferase-based silencing assays. Pretreatment of S2 cells with anti-Hsc70-4 antibody significantly reduced the internalization of Cy3-labeled dsRNA, suggesting Hsc70-4's involvement in the uptake process. Luciferase assays revealed a direct correlation between antibody concentration during pretreatment and decreased silencing efficiency, further supporting Hsc70-4's role as a dsRNA receptor. Finally, we evaluated the ability of Hsc70-4’s to bind dsRNA in vitro using electrophoretic mobility shift assays and found that Hsc70-4 binds specifically dsRNA in a sequence independent manner. Altogether, our experiments provide evidence that Hsc70-4 is expressed on the cell surface of drosophila cells where it may act as a receptor for extracellular dsRNA. These finding constitutes a previously undescribed function for Hsc70-4, and sheds light on the molecular mechanisms underlying insect antiviral defense. Invited by Suzanne Faure-Dupuy, Alberto De la Iglesia and Hugo Barreto, as part of the Post-doc seminar series. Plus d'infos... Tags: RNA, Molecular genetics, Gene expression, Ribonucleases, RNA interference, Small interfering RNA, Argonaute, HSPA8 Annonce publiée le 16-12-2023 |
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Institut Cochin Salle Rosalind Franklin |
Abstract: During growth and development, tissue dynamics, such as tissue folding, cell intercalations and oriented cell divisions, are critical for shaping tissues and organs. However, less is known about how tissues regulate their dynamics during tissue homeostasis and repair, to maintain their shape after development. In this talk, we will discuss how mechanical forces can influence each of these processes, such as how differential growth rates can generate precise folds in tissues. We will also discuss how tissues respond to mechanical perturbations, such as stretching or wounding, by altering their mechanical properties, to change tissue dynamics, and thus preserve tissue shape and patterning. We combine genetics, experimental biophysics and computational modelling across multiple animal model systems to study these processes.
Biosketch CV: Yanlan Mao is a Group Leader and Professor of Developmental Biophysics at the Laboratory for Molecular Cell Biology, University College London, and Deputy Director of the UCL Institute for the Physics of Living Systems. After receiving her BA in Natural Sciences (1st Class) at Cambridge University, she completed her PhD with Matthew Freeman at the MRC LMB in Cambridge on Drosophila cell signaling and epithelial patterning. During her postdoc with Nic Tapon at the CRUK London Research Institute (now Francis Crick Institute), she became interested in tissue mechanics and computational modeling approaches, and studied the role of mechanical forces in orienting cell divisions and controlling tissue shape. In 2014, Yanlan started her independent research group, and has continued to investigate the role of mechanical forces in tissue development, homeostasis and repair. She now holds an MRC Senior Fellowship, a Lister Institute Prize and an L’Oreal UNESCO Women in Science Fellowship. She was selected to join the EMBO Young Investigator Programme in 2018, and has received numerous awards for her work, including the Early Career Prize in Mechanobiology by the Biophysical Society, the BSCB Women in Cell Biology Early Career Medal, and the Royal Microscopic Society Life Sciences Medal. Plus d'infos... Tags: Cell biologists, Yanlan Mao, Stress, Psychological stress, Developmental biology, Cell division orientation Annonce publiée le 08-05-2024 |
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Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) |
Plus d'infos... Tags: Hepatitis, Peptide hormones, Fatty liver disease, Histopathology, Metabolic dysfunctionassociated steatotic liver disease, Liver, Glucose, Insulin Annonce publiée le 19-05-2024 |
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Centre de Recherche des Cordeliers amphitheatre Gustave Roussy, 15 rue de l'Ecole de Medecine - 75006 |
V(D)J recombination is essential for generating the adaptive immune response and unlimited number of different antibodies and antigen receptors. Encoded by multiple V, D and J gene segments, antigen receptors are assembled by programmed double-stranded DNA cleavage and imprecise re-joining. RAG1/2 recombinase initiates the process by stochastically cleaving DNA at a pair of recombination signal sequences (RSS) bordering the V, D or J gene segments. DNA double strand cleavage occurs in a single active site in two consecutive steps, hydrolysis and strand transfer, resulting in DNA hairpin on the coding end and DSB on the RSS side. Coding ends processing and joining to complete V, D, and J gene assembly and circularization of RSS end are carried out by the non-homologous end joining process (NHEJ). The DNA-dependent protein kinase (DNA-PK), consisting of the catalytic subunit (DNA-PKcs) and Ku70/80, is the key player in NJEJ by protecting broken DNA ends, promoting DNA hairpin end opening and also coordinating nucleotide removal, addition and DNA end ligation. In this seminar I will report the molecular mechanism of DNA cleavage by RAG1/2 and regulation of NHEJ by autophosphorylation of DNA-PKcs. Plus d'infos... Tags: Immunology, Immunity, Immune system Annonce publiée le 06-12-2023 |
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Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie |
Invited by the Ladoux/Mege Lab, Christophe Leterrier (Aix Marseille Universite?, CNRS, INP, NeuroCyto Lab) will present an IJM seminars on the theme: The axonal cytoskeleton down to the nanoscale Abstract: The intricate arborization and molecular identity of axons is maintained for decades, but must also continuously adapt to changes in the environment and modulate the activity of neurons. Axons fulfill these paradoxical demands thanks to a unique cytoskeletal organization that ensures the coordinated transport, anchoring and assembly of axonal components. In our lab, we use super-resolution microscopy to delineate and map the nanoscale architecture of cytoskeletal structures within the axon: the periodic actin/spectrin submembrane scaffold, intra-axonal hotspots and trails, presynaptic actin assemblies, clathrin-coated pits. We are exploring their molecular organization and functions by combining versatile labeling approaches, correlative live-cell/super-resolution/electron microscopy and quantitative analysis that allow for high-content, nanoscale interrogation of the axonal architecture. The seminar will take place on Friday, May Plus d'infos... Tags: Axon, Spectrin, Actin, Cytoskeleton, Neuron, Developmental neuroscience, Neurotrauma, Axonal transport Annonce publiée le 24-04-2024 |
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Institut Jacques Monod Usually at 11.45 am in the Francois Jacob room |
Invite par: Peter van Endert / Simon Fillatreau Agnes Lehuen is director of the Team Immunology of diabetes at Cochin Institute and University Paris City, France. She is cofounder of the Laboratory of Excellence INFLAMEX. Dr Lehuen's research has been focused on autoimmunity and metabolic diseases. Her laboratory has highlighted the key role of innate immune cells in the initiation or the prevention of type 1 diabetes, with a particular interest on NKT and MAIT cells. She also reported MAIT cell alteration and function in type 1 and type 2 diabetes, obesity and liver diseases. Her recent studies revealed that MAIT cell activation and cytotoxic function are associated with disease severity and mortality of COVID-19 patients. She presently investigates the role of MAIT cells in tissue damage upon enterovirus infection, as well as the crosstalk between MAIT cells and microbiota in diabetes.Seminar topic: MAIT cells: from metabolic diseases to viral infection Plus d'infos... Tags: Immunology, T cells, Immune system, MAIT, Autoimmunity, Type 1 diabetes, Microbiota, Diabetes, Mucosal-associated invariant T cell Annonce publiée le 18-05-2024 |
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Institut Necker Enfants Malades Auditorium 1 |
Plus d'infos... Tags: Oncology, Cancer, Metastasis, Small-cell carcinoma, Tumour heterogeneity, Pulmonary neuroendocrine tumor Annonce publiée le 15-05-2024 |
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Institut Cochin Salle Rosalind Franklin |
Invite par: ROUYER Francois Plus d'infos... Tags: Sensorimotor Annonce publiée le 17-05-2024 |
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NeuroPSI Salle de conference Albe-Fessard |
A venir Plus d'infos... Tags: Bourgogne-Franche-Comt, Forterre, Les Hauts de Forterre, Yoel Hernndez Annonce publiée le 18-05-2024 |
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Laboratoire Jean Perrin Laboratoire Jean Perrin - Campus Jussieu - T32-33, 5e etage - P.531 |
Plus d'infos... Tags: Neurochemistry, Neuropeptidergic, Neurotransmitters, Drosophila, Sensorimotor Annonce publiée le 17-05-2024 |
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NeuroPSI Salle de conference Albe-Fessard |
The transcriptional activities of developmental genes in time, in space, or in defined cell-types are orchestrated by repertoires of enhancers that communicate in the 3D nuclear space with target promoters. Transcriptional outcomes, necessary to instruct morphogenesis, also involve defined transcriptional durations over which a gene product exerts its function. This aspect implies that genes’ transcriptional activities are initiated in different cells and trans-environment than the one where they are maintained later on or eventually repressed. Despite this intuitive concept, little is known about the cis-regulatory components that enable it. Here, we have established the regulatory trajectory framework to track how regulatory landscapes control gene transcription in vivo over long developmental time periods. Gene regulatory trajectories first involve transcriptional initiation, which corresponds to the onset of gene expression, followed by maintenance over time, and finally decommissioning, leading to gene repression. Using fluorescent sensors and recorders, we can sort cell populations from embryos at different phases of regulatory trajectories to characterize transcription, chromatin states, and genome topologies. Furthermore, we can engineer complex alleles to assess the role of cis-regulatory regions in controlling the phases of a gene’s regulatory trajectory. In summary, our approach aims to characterize the lifespans of developmental gene regulation and their functional dependencies. Guillaume Andrey is invited by Antoine Zalc. Plus d'infos... Annonce publiée le 22-01-2024 |
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Institut Cochin Salle Rosalind Franklin |
Claude Desplan1,2, Nikos Konstantinides1, Felix Simon1, Neset Ozel1, Isabel Holguera1, Jennifer Malin1, Yen Chen1, and Bogdan Sieriebriennikov1
1 Center for Developmental Genetics, Department of Biology, New York University, New York, USA; 2 Center for Genomics and System Biology, NYU Abu Dhabi, UAE.
In the Drosophila optic lobes, ~250 neuronal types organized as 800 columns process the inputs from 800 unit-eyes. Neural stem cells in the medulla sequentially express a series of temporal transcription factors (tTFs), producing at each temporal window different neurons that innervate each of the 800 columns. We used single-cell mRNA sequencing to identify the tTFs that specify most medulla neurons. Each tTF regulates the progression of the series by activating the next tTF and repressing the previous one. Furthermore, the neuroepithelium that generates these stem cells is patterned into subdomains by spatial TFs: Although the series of tTFs is the same in stem cells originating from all spatial domains, the neurons they produce differ. Therefore, the integration of temporal and spatial patterning as well as Notch status, are sufficient to explain the generation of the entire neuronal diversity in this brain region. Finally, we will show how diversity in the brain can evolve to affect specific sensory functions in different species. I will describe the dramatically increased diversity in the mushroom body in ants as compared to flies, as ants rely extensively on pheromones rather than vision for their eusocial life. Plus d'infos... Tags: Claude Desplan, Desplan Annonce publiée le 15-04-2024 |
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Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) |
Invite par: JOVANIC Tihana Plus d'infos... Tags: Bad food, Pauls Annonce publiée le 04-05-2024 |
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NeuroPSI Salle de conference Albe-Fessard |
Plus d'infos... Annonce publiée le 12-12-2023 |
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Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris |
Plus d'infos... Annonce publiée le 18-05-2024 |
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Inst. Bio. Paris Seine 7-9 quai Saint Bernard, 75005 Paris |
Invite par: CIRB - College de France Plus d'infos... Tags: @CirbCdf Annonce publiée le 29-04-2024 |
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College de France Amphitheatre Marguerite de Navarre, 11 place Marcelin-Berthelot, 75005 Paris |
Invited by the Duharcourt lab, Nick Irwin (Gregor Mendel Institute, Vienna BioCenter) will present an Institut Jacques Monod Seminar on the theme: Self-assembling viral histones unravel early nucleosome evolution Abstract: The nucleosome is a defining feature of eukarytoes that plays a central role in the coordination and regulation of the genome. Accordingly, understanding the origin of the nucleosome is essential for interpreting how eukaryotes evolved from prokaryotic ancestors. The strong conservation of the nucleosome and its histone constituents makes reconstructing nucleosome evolution challenging, but divergent histone homologues found in large double stranded DNA viruses could provide a new perspective for interpreting the evolution of this complex. By surveying viral diversity, we identified hundreds of viral histones with unique protein architectures, including histone quadruplets which comprise the four core histones linked in series. These viral histones branch phylogenetically between Archaea and eukaryotes and display intermediate structural and functional characteristics, self-assembling into eukaryotic-like nucleosomes that stack into archaeal-like oligomers. Finally, we demonstrate how histone linkage can facilitate nucleosome assembly, permitting the formation of animal nucleosomes in the bacterium The seminar will take place on Friday, June 7th at 11.45 am in room Francois Jacob (15 rue Helene Brion 75013 Paris) Plus d'infos... Tags: Epigenetics, Molecular biology, Nuclear organization, Nucleosome, Histone, HIST1H2BL, HIST1H2BO Annonce publiée le 11-05-2024 |
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Institut Jacques Monod Usually at 11.45 am in the Francois Jacob room |
Invite par: Chris BOWLER - Seminaire EEB Plus d'infos... Annonce publiée le 16-05-2024 |
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IBENS salle Favard, IBENS 46 rue d'Ulm 75005 Paris |
Invite par: CIRB - College de France Plus d'infos... Annonce publiée le 29-04-2024 |
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College de France Amphitheatre Marguerite de Navarre, 11 place Marcelin-Berthelot, 75005 Paris |
Hydra is named after the mythological animal for its regenerative capabilities, but contrary to its mythological counterpart, it only regenerates one head when cut. Here we show that soft compression of head regenerating tissues induces the regeneration of viable, two headed animals. Topological defects in the supracellular nematic organization of actin were previously correlated with the new head regeneration site1. Soft compression creates new topological defects associated with additional heads. To test the necessity of topological defects in head regeneration, we changed the topology of the tissue. By compressing the head regenerating tissues along their body axis, topological defects of the foot and of the regenerating head fused together, forming a toroid with no defects. Perfectly ordered toroids did not regenerate over eight days and eventually disintegrated. Spheroids made from excised body column tissue partially lose their actin order during regeneration. Compression of spheroids generated toroids with actin defects. These tissues regenerated into toroidal animals with functional head and foot, and a bifurcated body. Our results show that topological defects in the actin order are necessary to shape the head of the regenerating Hydra, supporting the notion that actin topological defects are mechanical organizers of morphogenesis. Plus d'infos... Annonce publiée le 14-05-2024 |
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Institut Curie Centre de recherche - Paris - Amphitheatre IPGG - 6 rue Jean Calvin, Paris 5e |
Flocking is a prime example of how robust collective behaviours can emerge from simple interaction rules. The famous Vicsek model displays a transition from disorder to flocking by varying different system parameters, and has been well-studied since its conception in 1995; however, the generalisation to heterogeneous interactions has been given less attention. Here, we consider adding quenched disorder in the alignment interactions to a self-propelled particle model, in the form of Gaussian distributed couplings. By increasing the standard deviation of the coupling distribution, we find the emergence of significant global polar order in systems where the majority of couplings are anti-aligning. I will present these numerical findings and investigate the self-organisation mechanism by which this phenomenon occurs. Plus d'infos... Tags: Multi-agent systems, Zoology, Group processes, Complex systems theory, Ethology, Self-propelled particles, Vicsek model, Tams Vicsek, Flocking, Self-propelled, Self-organization, Particle system Annonce publiée le 18-05-2024 |
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Laboratoire Jean Perrin Laboratoire Jean Perrin - Campus Jussieu - T 32-33 - 5e et. - P533 |
Les sarcomères sont des dispositifs musculaires générateurs de force et porteurs de charge. Une image moléculaire précise de la façon dont les sarcomères sont construits permet de comprendre leur rôle dans la santé et les maladies. Nous avons déterminé l'architecture moléculaire des sarcomères squelettiques et cardiaques natifs et les structures des protéines sarcomères en utilisant le broyage par faisceau d'ions cryo-focalisé (cryo-FIB) et la cryo-tomographie électronique (cryo-ET). Notre reconstruction tridimensionnelle du sarcomère révèle des détails moléculaires dans la bande A, la bande I et le disque Z et démontre l'organisation des filaments fins et épais ainsi que leurs liaisons croisées [1,2]. Notre reconstruction du filament épais révèle l'organisation tridimensionnelle des têtes et queues de myosine, de la protéine C liant la myosine (MyBP-C) et de la titine, élucidant la base structurelle de leur interaction lors de la contraction musculaire [2]. En utilisant la moyenne sous-tomogramme, nous avons déterminé une structure in situ d'une protéine nébuleuse liant les filaments fins, la nébuline, à 4,5 Å et démontré le mécanisme moléculaire sous-jacent à son rôle de « règle moléculaire », dans la stabilisation des filaments fins et dans la régulation de la myosine. liaison [3]. Nous avons également caractérisé la structure d'une conformation unique de myosine à double tête, mettant en évidence la variabilité structurelle inhérente de la myosine dans le muscle [1]. References [1] Wang, Z, Grange M et al. (2021), Cell. 184,2135-2150.613 [2] Tamborrini, D et al. (2023), Nature, in press [3] Wang, Z, Grange M et al. (2022), Science. 375, eabn1934 Plus d'infos... Annonce publiée le 29-04-2024 |
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Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie |
Each limb muscle is unique with a specific shape, size and insertions to bone via connective tissues, so the developmental programs of muscle and associated connective tissues have to be tightly regulated to achieve the final muscle pattern. Although each limb muscle is unique, every muscle displays the same organization, they are all attached to tendons at both extremities and innervated at the center of muscle, defining the muscle domains. We found that muscle fusion is not homogenous within muscle but organized according to these domains. We also identified an unexpected recruitment of fibroblast nuclei in muscle fibers, recruitment localized at muscle tips, close to tendon. The spatial regulation of myogenesis is important to shape limb muscles during development. Delphine Duprez is invited by Pascal Maire. Plus d'infos... Tags: Muscular system, Myogenesis, Muscle, Skeletal muscle, Myogenin Annonce publiée le 06-03-2024 |
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Institut Cochin Salle Rosalind Franklin |
Invite par: Gabrielle Girardeau Plus d'infos... Tags: Scarborough, Arruda, Santa Cruz Futebol Clube Annonce publiée le 30-04-2024 |
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Insitut du Fer à Moulin 17 Rue du Fer a Moulin - 75005 Paris |
Uveal melanoma is the most common eye cancer in adults with a set of highly characteristic genetic alterations. We identified mutations in the BAP1 (BRCA1 Associated Protein 1) gene in uveal melanomas with high likelihood of metastasis and recurrent mutations in the splicing factor SF3B1 with less chance of metastasis. Other alterations in this aggressive tumor include early oncogenic changes that are found in all tumor classes as well as characteristic copy number changes. In order to further characterize molecular alterations that drive tumorigenesis and metastasis we have performed long-read single molecule sequencing (SMRT) of DNA from primary UMs with different driver mutations to develop detailed maps of the structural variations (SVs) of the genomes of these tumors, and identified and characterized critical breakpoints, gene fusions and tumor specific isoforms. We have also used an eye organoid model (SEAM) to investigate the consequences of BAP1 loss, and the power of fly genetics to dissect the roles of the different genetic drivers. We have generated and characterized flies with loss of function mutations in the BAP1 ortholog calypso, and generate activating mutations of the GNAQ ortholog GαQ so that the combined effect of loss of calypso and activation of GαQ can be investigated. We have focused on larval eye discs and wing discs that represented well-ordered epithelial monolayers and examined the the phenotypic, signaling and epigenomic changes that arise from these mutations. We have also tested drug targets affecting viability of UM lines for the ability to modify the cancer-like phenotypes seen in our one- and two-hit GαQ and calypso fly model. Genetic suppressors of overgrowth, tissue transformation, and metastasis phenotypes represent exciting therapeutic candidates to pursue in future studies. These studies are providing further insights into the roles of alterations leading to UM, and potentially novel targets for treatment. Plus d'infos... Annonce publiée le 14-05-2024 |
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Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) |
TBA Plus d'infos... Tags: Draft:List of wars lost by israel, Mister RNB Espaa Annonce publiée le 18-05-2024 |
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Laboratoire Jean Perrin Salle de seminaires 5eme etage - LJP - Tours 32-33 |
Invited by Sylvaine You. Plus d'infos... Tags: Nathalie, Hlne Labarrire Annonce publiée le 29-02-2024 |
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Institut Cochin Salle Rosalind Franklin |
Invited by the Konstantinides, Ezzat El-Sherif (School of Integrative Biological and Chemical Sciences, University of Texas Rio Grande Valley, Edinburg, Texas, US) will present an Institut Jacques Monod Seminar on the theme: How enhancers translate time into space during development Abstract: In embryonic development, is time more important or space? Conventionally, the answer would be: Both! However, recent studies on various embryonic tissues emphasize the primacy of time, showing that spatial gene expressions often stem from converting temporal gene sequences, both periodic and non-periodic, into spatial patterns. This phenomenon has been proposed (by my work and others) to result from the modulation of embryonic timing by morphogen gradients. Yet, the specific molecular mechanisms through which morphogen gradients modulate developmental timing remain unknown. In our work, we used the Anterior-Posterior patterning of the short-germ beetle Tribolium as a model to explore how developmental timing is modulated at the enhancer level. We first developed a predictive system to identify Tribolium enhancers, using time- and tissue-specific ATAC-seq. We then developed a live enhancer reporter system utilizing MS2 tagging. This methodology allowed us to discover several Tribolium enhancers and to investigate the spatiotemporal dynamics of select enhancers in live embryos. Our findings suggest a model in which embryonic timing is regulated by a balance between two types of enhancers: #8216;dynamic enhancers,#8217; which prompt rapid changes in gene expression, and #8216;static enhancers,#8217; which contribute to the stabilization of gene expression patterns. Plus d'infos... Tags: Gene expression, Morphogens, Enhancer, Shavenbaby, Shadow enhancer Annonce publiée le 07-05-2024 |
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Institut Jacques Monod Usually at 11.45 am in the Francois Jacob room |
Invite par: Laurent BOURDIEU - Section Neurosciences Plus d'infos... Tags: Cognitive science, Experimental psychology, Neuropsychological assessment, Perception Annonce publiée le 17-05-2024 |
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IBENS salle Favard, IBENS 46 rue d'Ulm 75005 Paris |
Invite par: Cassandra Koh Keywords: Genome instability, DNA replication, replication stress, centromere, DNA damage Plus d'infos... Tags: DNA replication, Chromosomes, Molecular genetics, Cell cycle, DNA replication stress, Centromere, Genome instability, S phase, DNA Annonce publiée le 29-12-2023 |
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Institut Pasteur Batiment JACOB , salle Auditorium Francois JACOB , |
Aging is associated with the accumulation of senescent cells and the increase of systemic inflammation. At the cellular level, aneuploidy gradually increases with age, suggesting that centromeric function may be dysregulated during aging, thereby contributing to senescence and inflammaging. Here, we investigated the regulation of centromere integrity in T lymphocytes, which exhibit age-associated aneuploidy and senescent cell accumulation. We have found that resting human lymphocytes from adults harbor a significant population of cells expressing low levels of total CENP-A, while CENP-B and CENP-C levels are not affected. Notably, CENP-A-low cells show lower or non-detectable CENP-A loaded at centromeres, indicating a change in centromere identity. In contrast, T cells from newborns do not exhibit this population. Furthermore, CENP-A-low T cells are not equally distributed among subsets of adult T cells. This indicates that the CENP-A-low state is associated with age-dependent changes and the functional state of T cells. In vitro, activated T cells in which we have recapitulated this defective centromere structure by genetic knock-out of CENP-A, show a senescent phenotype characterized by the upregulation of p53 target genes and the expression of proinflammatory genes. In addition, CENP-A knock-out T cells display chromosome-specific aneuploidy after proliferation. Overall, our results reveal that centromere structure integrity is impacted through lifespan and determines aneuploidy in T cells, contributing to regulation of senescence and inflammation. Invited by Suzanne Faure-Dupuy, Alberto De la Iglesia and Hugo Barreto, as part of the Post-doc seminar series. Plus d'infos... Tags: Cell biology, Senescence, Chromosomal abnormalities, Cytogenetics, Cells, Cellular senescence, Centromere, Inflammaging, Aneuploidy, T cell, Kinetochore, Tim J. Yen Annonce publiée le 16-12-2023 |
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Institut Cochin Salle Rosalind Franklin |
Invited by par the Duharcourt, Gaelle Legube (CBI, Toulouse) will present an Institut Jacques Monod seminar on the theme: Chromosome and chromatin dynamics at DNA double strand breaks Abstract: DNA double-strand breaks (DSBs) are highly toxic lesions that are rapidly repaired by two main pathways, namely Homologous Recombination (HR) and Non Homologous End Joining (NHEJ). Using a cell line, called DIvA (for DSB Inducible via AsiSI), where multiples breaks are induced at annotated positions, combined with genome-wide, high throughput sequencing based techniques (ChIP-seq, HiC#8230;) we investigate the contribution of chromatin and chromosome conformation in the response to DSB. I will present our recent work, on the contribution of chromatin and Topologically Associating Domains (TADs) during DSB repair. More specifically we recently demonstrated the role of cohesin-mediated loop extrusion in establishing gammaH2AX on an entire TAD in cis to DSBs. We now provide evidence that when established, gammaH2AX tagged TAD further self-segregate in the nucleus, forming a novel DSB-induced chromatin compartment (the D compartment) that contributes to the activation of the DNA damage response. The seminar will take place on Friday, June 28th at 11.45 am in room Francois Jacob (15 rue Helene Brion 75013 Paris) Plus d'infos... Tags: DNA repair, H2AFX, DNA damage, Chromatin, Cohesin, Homologous recombination, Non-homologous end joining, Topologically associating domain, Meiotic recombination checkpoint, Double-strand break repair model Annonce publiée le 16-05-2024 |
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Institut Jacques Monod Usually at 11.45 am in the Francois Jacob room |
Facioscapulohumeral muscular dystrophy (FSHD) is a complex neuromuscular disorder characterized by progressive weakness and atrophy of specific groups of muscles. Despite significant advancements in research, elucidating the precise pathophysiological mechanisms underlying FSHD remains a challenging endeavor. To tackle this challenge, we developed an integrated and interdisciplinary approach starting from genotype identification to tissue bioengineering to unravel the intricacies of FSHD pathophysiology.
Leveraging advancements in genomic technologies, we uncovered novel genetic variants and modifiers implicated in FSHD, expanding our understanding beyond the canonical genetic defect.
To complement genotype-based studies, we recently developed tissue bioengineering approaches to recapitulate the FSHD phenotype in vitro.
By considering the diversity of patient’s genotype, this interdisciplinary approach offers a comprehensive framework for dissecting FSHD pathophysiology from a molecular to a cellular level for the identification of the molecular cascades driving disease progression toward the development of treatment strategies. Frédérique Magdinier is invited by Pascal Maire. Plus d'infos... Tags: Facioscapulohumeral muscular dystrophy, Muscular dystrophy, Phenotype Annonce publiée le 29-02-2024 |
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Institut Cochin Salle Rosalind Franklin |
Invited by Julie Helft. Plus d'infos... Tags: Vanja, Julie Annonce publiée le 09-03-2024 |
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Institut Cochin Salle Rosalind Franklin |
Early human development remains mysterious and difficult to study. Recent advances in developmental biology, stem cell biology and bioengineering have contributed to a significant interest in constructing controllable, stem cell-based models of human embryo and organs (embryoids / organoids). The controllability and reproducibility of these human development models, coupled with the ease of genetically modifying stem cell lines, the ability to manipulate culture conditions and the simplicity of live imaging, make them robust and attractive systems to disentangle cellular behaviors and signaling interactions that drive human development. In this talk, I will describe our effort in using human pluripotent stem cells (hPSCs) and bioengineering tools to develop controllable models of the peri-implantation embryonic development and early neural development. The peri-implantation human embryoids recapitulate early post-implantation developmental landmarks, including amniotic cavity formation, amniotic ectoderm-epiblast patterning, primordial germ cell specification, development and organization of embryonic germ layers, yolk sac formation, and primitive hematopoiesis. I will further discuss an hPSC-based, microfluidic neural tube-like structure (or µNTLS), whose development recapitulates some critical aspects of neural patterning in both brain and spinal cord regions and along both rostrocaudal and dorsoventral axes. The µNTLS is further utilized for studying development of different neuronal lineages, revealing pre-patterning of axial identities of neural crest progenitors and a role of neuromesodermal progenitors in spinal cord and trunk neural crest development. We have further developed dorsoventral patterned, microfluidic forebrain-like structures (µFBLS) with spatially segregated dorsal and ventral regions and layered apicobasal cellular organizations that mimic human embryonic brain development in pallium and subpallium areas, respectively. Together, both µNTLS and µFBLS offer 3D lumenal tissue architectures with an in vivo-like spatiotemporal cell differentiation and organization, useful for studying human neurodevelopment and disease. Plus d'infos... Tags: Embryology, Human embryonic development, Embryo donation, Ectogenesis Annonce publiée le 22-04-2024 |
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Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie |
Nicolas Reynoird is invited by Frédéric Pendino. Plus d'infos... Tags: Dauphin, Grenoble Annonce publiée le 19-03-2024 |
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Institut Cochin Salle Rosalind Franklin |
Objectifs pédagogiques de la formation - Connaître les définitions légales des violences sexistes et sexuelles Pour rejoindre le séminaire : https://shorturl.at/awJU0 Séminaire proposé par la 'Cellule de prévention RPS-VSS' du Centre de Recherche Plus d'infos... Annonce publiée le 06-02-2024 |
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Institut Curie Centre de recherche - Paris - Webinar |
Invitées par Sophie Vaulont. Plus d'infos... Annonce publiée le 15-03-2024 |
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Institut Cochin Salle Rosalind Franklin |
Le cours réunira des intervenants de premier plan issus de différents domaines de la biologie des systèmes cancéreux, de la recherche sur le cancer et de la clinique. Les orateurs invités exposeront diverses approches pour l'analyse et l'interprétation des données omiques, d'imagerie et cliniques, en combinant les réseaux de signalisation avec des données moléculaires multi-échelles, et en les associant à des données cliniques. Les thèmes abordés comprennent l'intégration et l'analyse de données génomiques multimodales, les algorithmes de prédiction de la sensibilité aux médicaments, l'identification de biomarqueurs et de facteurs de cancer, la stratification des patients, et les applications de la modélisation mathématique et de l'analyse d'images dans le domaine du cancer.
L'objectif du cours est de promouvoir une meilleure intégration des approches informatiques dans les laboratoires biologiques et cliniques et dans les cliniques. Nous voulons aider les participants à comprendre et à utiliser les approches d'intégration multimodale pour exploiter efficacement les différents types de données qui s'accumulent dans la plupart des laboratoires biologiques ou médicaux. Le cours passera en revue les méthodes et outils actuels pour l'analyse et l'interprétation des données génomiques multimodales, en mettant l'accent sur la transcriptomique et la protéomique spatiales récentes, ainsi que sur des applications concrètes liées au cancer. En particulier, le cours présentera des méthodes informatiques nous permettant d'approfondir notre compréhension de l'hétérogénéité des tumeurs, de tirer parti de l'intégration multimodale des données cliniques et omiques, et de concevoir des schémas de traitement personnalisés. Plus d'infos... Annonce publiée le 25-04-2024 |
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Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) |
Invite par: Laura Cantini The Targeted Technological Action on Artificial Intelligence (ATC-IA) is organizing the second edition of its Symposium Artificial Intelligence in Biology and Health. It will be held on 4th October 2024 in the Emile ... Plus d'infos... Tags: IA, Artificial intelligence Annonce publiée le 04-03-2024 |
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Institut Pasteur Batiment: Emile Duclaux Salle: Lecture Hall |
Over the past two decades, there has been a significant shift in our understanding of the role of endocytosis and trafficking of signaling receptors. It has evolved from being viewed simply as a signal extinguisher (resulting in long-term attenuation) to being recognized as a sophisticated mechanism capable of delivering signals to specific cellular locations with precise timing. Therefore, endocytosis functions as a regulatory program that impacts various aspects of cell physiology, and we have evidence suggesting that alterations in this program may be causal and targetable in cancer. On the one hand, by exploiting the EGFR model system, we obtained confirmation that the integration of the two functions of endocytosis (sustainment and attenuation of signals) might be achieved, at least in part, at the plasma membrane (PM) by activation of different endocytic routes. Disruption of this balance appears to contribute significantly to cancer cell proliferation, invasion, and metastasis. On the other hand, our research has demonstrated the causal role of an endocytic protein, Epsin3 (EPN3), in breast cancer development, particularly in association with the emergence of partial epithelial-to-mesenchymal transition (pEMT), cancer stem cells, and invasive phenotypes. Increased E-cadherin endocytosis is the initial event driving EPN3-induced pEMT, that render cells more plastic and prone to metastatic dissemination. Importantly, inhibition of increased E-Cadherin endocytosis is capable of reversing EPN3-dependent invasiveness. The restricted expression of EPN3 in adult tissues, along with its overexpression in breast cancer, positions EPN3-drived endocytosis as a promising target for therapeutic intervention. Plus d'infos... Tags: Memory, Neurophysiology, Neuroplasticity, Neural circuits, Brain Annonce publiée le 27-02-2024 |
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Institut Curie Centre de recherche - Paris - Amphitheatre Marie Curie |
Long version (3,5 weeks, w/ practicals at Sorbonne University & Seminars at Institut Curie) : July 20th Institut Curie and Sorbonne Université organize their 15th International Developmental Biology course. The aim of the program is to provide the participants a comprehensive coverage of the paradigms, problems and technologies of modern Developmental Biology paying particular attention to stem cells. Training in theoretical and experimental aspects of normal and abnormal development is developed through a variety of embryonic systems using state-of-the-art instrumentation and methodology. The program is proposed in two versions (more information available soon) so there will be two registration deadlines: Plus d'infos... Tags: Developmental biology, Evolutionary developmental biology, Morphogenesis, Morphology, Stem cells, Morphogen Annonce publiée le 17-05-2024 |
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Institut Curie Centre de recherche - Paris - Amphitheatre Helene Martel-Massignac (BDD) |